Rituximab’s Efficacy in Patients With Hypersensitivity Reactions

نویسندگان

چکیده

Background: The B-cell antigen CD20 is expressed on normal B-cells and almost all lymphomas. This non-modulating agent provides an excellent target for antibody-directed therapeutic regimens. IDECC2B8 (rituximab) a monoclonal antibody (mAb) directed against the B-cell-specific CD20. mediates complement antibody-dependent cell-mediated cytotoxicity. As its usage has surged, there have been growing concerns about rituximab-related infusion reactions. Approximately 1/4th of patients receiving first administration show reactions, most time they are re-challenged safely. Since recent studies reported presence serum anti-rituximab antibodies in who develop hypersensitivity we evaluating pharmacodynamic response rituximab with it.

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ژورنال

عنوان ژورنال: Journal of pharmaceutics & pharmacology

سال: 2023

ISSN: ['2327-204X']

DOI: https://doi.org/10.13188/2327-204x.1000034